Phase 1b Clinical Trial of AN0025 Begins - The first Patient Dosed

Date: 2020-08-25   Author: Pankaj Singh  Category: #market

Phase 1b Clinical Trial of AN0025 Begins - The first Patient Dosed

Adlai Nortye Ltd., a global biopharmaceutical company dedicated to developing innovative treatments for cancer, stated that in a phase 1b clinical trial (AN0025S0103), the first patient is been dosed to evaluate AN0025. It is a unique oral EP4 antagonist with Merck's KEYTRUDA® in patients with locally advanced or metastatic solid tumors.

AN0025S0103 is an open-label, phase 1b study in the U.S. and Europe to assess the safety and primary effectiveness of AN0025 with pembrolizumab in patients with locally advanced or metastatic tumors. The study will include a dose-limiting toxicity observation stage which will be followed by an expansion phase.

In the dose-limiting toxicity stage of the study, it will register patients with urothelial carcinoma of the bladder or non-Squamous NSCLC or squamous to evaluate safety and tolerability. The progress of this stage will decide whether to move on to the expansion stage or not. This will enroll patients diagnosed with NSCLC, urothelial carcinoma, TNBC, MSS CRC, and Cervical cancer. The first patient was dosed at the University of Utah at Huntsman Cancer Institute (HCI). Patients from The University of Virginia Cancer Center and The University of Texas MD Anderson Cancer are also enrolled in the study.

All the registered patients will be treated with pembrolizumab and AN0025 until the patient experiences disease development, intolerable toxicity, or removes consent, or for around 2 years (max 3 cycles). for each dose level of AN0025, the dose of Pembrolizumab will be kept constant at 200 mg every 3 weeks.

The CDO and CEO of Adlai Nortye USA, Dr. Lars Birgerson stated that AN0025 combined with chemoradiotherapy, radiotherapy, and immune checkpoint inhibitors in the preclinical studies showed antitumor activity in different malignancies. While being hopeful about the combination of AN0025 with KEYTRUDA®, Dr. Birgerson confirmed that it can be beneficial for patients with locally advanced or metastatic solid tumors. This combination can provide treatment to numerous cancer patients. The team hopes to bring advanced cancer treatment to help patients live a longer and better life.

 

Source: https://www.benzinga.com/pressreleases/20/08/n17203481/adlai-nortye-announces-first-patient-dosed-in-phase-1b-clinical-trial-of-an0025-ep4-antagonist-in-



About Author


Pankaj Singh linkdin-boxtwitter

Pankaj Singh

Pankaj Singh Develops content for Algosonline, Market Size Forecasters, and a couple of other platforms. A Post Graduate in Management by qualification, he worked as an underwriter in the UK insurance domain before deciding to switch his field of profession. With exp...

Read More

Post Recommendents

Cable Cutting Shears Sales Market to Witness an Outstanding Growth During 2021- 2027

Author: Sachin Pashte

The Cable Cutting Shears Sales market study now available with Market Study Report, LLC, is a collation of valuable insights related to market size, market share, profitability margin, growth dynamics and regional proliferation of this business ve...


Hard Kombucha Sales Market Size and Forecasts Research Report 2021-2027

Author: Sachin Pashte

MarketStudyReport.com presents latest report on global Hard Kombucha Sales Market, which evaluates the growth trends of the industry through historical study and estimates future prospects based on comprehensive research. The report extensively pr...


Ultrasonic Testing Probes Market to Deliver Prominent Growth & Striking Opportunities Scenario Highlighting Major Drivers & Trends 2021-2027

Author: Sachin Pashte

Ultrasonic Testing Probes market provides accurate analysis of the vertical with respect to valuation forecasts, competitive intelligence, growth drivers, risks & limitations, Covid-19 impact, and other important subjects.

The recent...