Arcus & Gilead close option exercises for three programs & partnership

Date: 2021-12-22   Author: Pankaj Singh  Category: #news

Arcus & Gilead close option exercises for three programs & partnership

Arcus Biosciences Inc. and Gilead Sciences Inc. have reportedly announced the closure of option exercises of Gilead to three programs in the clinical-stage collection of Arcus and a new research partnership among the two firms.

Gilead leveraged the options to AB308 and domvanalimab, the anti-TIGIT molecules along with clinical candidates quemliclustat (small molecule CD73 inhibitor) and etrumadenant (dual adenosine A2a/A2b receptor antagonist).

The closing took place following the termination of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act.

As part of the conditions of the Option, License, and Collaboration Agreement as amended in relation with the three option exercises of Gilead, the closure of this transaction activates option payments of over USD 725 million to Arcus from Gilead which is expected to be paid early in the first quarter of 2022.

With the closure of the transaction for all three programs, the USD 100 million option payment which was previously due in Q3 2022 will not be made by Gilead. Additionally, the parties will develop together and share the global costs pertaining to these clinical programs.

If the optioned molecules attained regulatory approval, Arcus and Gilead will equally share profits and co-commercialize in the United States. Outside of the United States, Gilead holds exclusive rights of commercialization subject to any rights of the current collaboration partners of Arcus and Gilead would pay tiered royalties to Arcus on net sales of every optioned product.

It should be noted that Arcus and Gilead signed a 10-year partnership in May 2020 that offered Gilead the right to opt into all other programs of Arcus rising during the term of the collaboration, along with immediate rights to zimberelimab.

Arcus and Gilead amended the partnership in relation to the option exercise of Gilead for three clinical-stage programs of Arcus. For all new programs that enter clinical development or other programs that are into clinical development, the opt-in payments are USD 150 million per program.

Source credit:

About Author

Pankaj Singh linkdin-boxtwitter

Pankaj Singh

Pankaj Singh Develops content for Algosonline, Market Size Forecasters, and a couple of other platforms. A Post Graduate in Management by qualification, he worked as an underwriter in the UK insurance domain before deciding to switch his field of profession. With exp...

Read More

Post Recommendents

Swiss-based Lonza acquires Synaffix to expand its ADCs portfolio

Author: Pankaj Singh

Lonza, a leading pharmaceutical company based in Switzerland, has reportedly expanded its antibody-drug conjugates (ADCs) portfolio with the acquisition of Dutch biotechnology business, Synaffix for a total consid...

Xiomi partners with Indian assembler Dixon to strengthen supply base

Author: Pankaj Singh

Xiaomi, the leading Chinese smartphone manufacturer, has reportedly collaborated with an Indian contract company, Dixon Technologies, for the manufacturing and export of its mobile phones. This move aligns with the Chi...

UAE’s ITC, Google join forces to leverage AI data & technologies

Author: Pankaj Singh

Abu Dhabi Department of Municipalities and Transport’s Integrated Transport Centre (ITC) has reportedly signed two agreements with Google in a bid to showcase the country’s efforts aimed towards advancing i...